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Journal Article 3

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2020 1

2018 1

2007 1

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3-Acylthiotetronic acid 1

Phytophthora infestans 1

Antifungal activity 1

Fungicide 1

Ginkgo biloba L. 1

Quantitative structure-activity relationship 1

Yintai 1

bionic synthesis 1

control effect 1

ginkgol 1

late blight 1

mathematical model 1

potato 1

retrospective analysis 1

yield losses 1

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a weather-based model to determine potential yield losses caused by potato late blight and optimize fungicide

Alexey FILIPPOV, Maria KUZNETSOVA, Alexander ROGOZHIN, Olga IAKUSHEVA, Valentina DEMIDOVA, Natalia STATSYUK

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4, Pages 462-468 doi: 10.15302/J-FASE-2018239

Abstract: To minimize yield losses, various protective measures are used including fungicide application.disease development between these regions and may be used to develop recommendations for a frequency of fungicideapplications according to the regional risk of epidemics, leading to a significant reduction in fungicide

Keywords： potato late blight Phytophthora infestans yield losses retrospective analysis mathematical model

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Research on Bionic Fungicide Yintai and Its Application

Meng Zhaoli,Fang Xiangyang,Luo Lan,Shang Jian

Strategic Study of CAE 2007, Volume 9, Issue 3, Pages 28-34

Abstract:

Yintai (p-hydroxy butrophenone) is a kind of bionic fungicides synthesized by simulating the lead compound of ginkgol isolated from the exosperm of ginkgo fruit. 8.3-time diluted solution of alcohol crude extract from the ginkgo fruit showed 100% inhibtion on the pathogen of apple canker (Valsa mali), and 50% inhibition for the 25-time solution. Both 200-time and400time solutions of ginkgol, extracted from external seed coat of ginkgo, had 100% inhibition on pathogen of apple canker(Valsa mali). EC₅₀ of 20% Yintai ME against4kinds of pathogens, including apple canker, tomato gray mold, and so on, ranges from 17.26 mg/L to 48.43 mg/L, better than the contrast chemicals respectively. Field control effects on4kinds of diseases, e.g. , Rhizoctonia cerealis, are higher than 85%, with safety to non-target organisms, and no symptom of pesticide resistance. Both LD50of acute oral toxicity and LD₅₀of acute dermal toxicity to mouse are 4640 mg/kg by Yintai technical material, and 3160 mg/kg and 2150 mg/kg by 20% Yintai EC coorespondingly. Trials of subchronic toxicity (90days) revealed that oral toxicity was 19.1 mg/kg for female, and 18.3 mg/kg for male, with negative results on Ames test, micro-nucleus test, and chromosome-type aberration test.

Keywords： Ginkgo biloba L. ginkgol bionic synthesis Yintai control effect

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Synthesis, Characterization, and Antifungal Evaluation of Thiolactomycin Derivatives Article

Pei Lv, Yiliang Chen, Dawei Wang, Xiangwei Wu, Qing X. Li, Rimao Hua

Engineering 2020, Volume 6, Issue 5, Pages 560-568 doi: 10.1016/j.eng.2019.10.016

Abstract:

5-Substituted benzylidene 3-acylthiotetronic acids are antifungal. A series of 3-acylthiotetronic acid derivatives with varying substitutions at the 5-position were designed, synthesized, and characterized, based on the binding pose of 3-acyl thiolactone with the protein C171Q KasA. Fungicidal activities of these compounds were screened against Valsa Mali, Curvularia lunata, Fusarium graminearum, and Fusarium oxysporum f. sp. lycopersici. Most target compounds exhibited excellent fungicidal activities against target fungi at the concentration of 50 μg·mL⁻¹. Compounds 11c and 11i displayed the highest activity with a broad spectrum. The median effective concentration (EC₅₀) values of 11c and 11i were 1.9–10.7 and 3.1–7.8 μg·mL⁻¹, respectively, against the tested fungi, while the EC₅₀ values of the fungicides azoxystrobin, carbendazim, and fluopyram were respectively 0.30, 4.22, and > 50 μg·mL⁻¹ against V. Mali; 6.7, 41.7, and 0.18 μg·mL⁻1 against C. lunata; 22.4, 0.42, and 0.43 μg·mL⁻¹ against F. graminearum; and 4.3, 0.12, and > 50 μg·mL⁻¹ against F. oxysporum f. sp. Lycopersici. The structures and activities of the target compounds against C. lunata were analyzed to obtain a statistically significant comparative molecular field analysis (CoMFA) model with high prediction abilities (q² = 0.9816, r² = 0.8060), and its reliability was verified. The different substituents on the benzylidene at the 5-position had significant effects on the activity, while the introduction of a halogen atom at the benzene ring of benzylidene was able to improve the activity against the tested fungi.